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Let's Talk GLP-1
The health challenge
Maintaining balanced blood sugar levels is crucial for overall health and well-being. When we consume sugar or starches, our bodies break them down into glucose, which serves as a primary energy source. In a healthy individual, insulin helps cells absorb glucose from the bloodstream, keeping blood sugar within an optimal range. However, when this balance is disrupted, persistently elevated blood sugar can lead to various health challenges, including increased oxidative stress, low-grade inflammation, insulin resistance, and impaired cardiovascular function.
GLP-1: The body's blood sugar regulator

GLP-1, or glucagon-like peptide-1, is an incretin hormone produced in the intestine that plays a crucial role in regulating blood sugar levels. After we eat, the presence of nutrients (carbohydrate, protein and lipids) triggers the release of GLP-1 that stimulates insulin secretion from the pancreas while suppressing the release of glucagon, a hormone that promotes glucose release from the liver. This dual action helps keep blood sugar levels in check.

In addition to its effects on insulin and glucagon, GLP-1 slows gastric emptying, promoting feelings of fullness and satiety, which may support healthy weight management goals.

However, maintaining optimal GLP-1 levels in the blood can be challenging, as the hormone is rapidly broken down by an enzyme called DPP-4. This limits GLP-1's ability to effectively regulate blood sugar, particularly in those with impaired glucose metabolism and insulin resistance.

While pharmaceutical interventions like DPP-4 inhibitors and GLP-1 receptor agonists can help, they may come with potential side effects and may not be suitable for everyone.

Our science-backed solution

Eriomin® is a clinically-studied, patent-protected ingredient that harnesses the potential of lemon flavonoids to support healthy GLP-1 function and glucose metabolism. Derived from lemons using a proprietary extraction process, Eriomin is standardized to contain high levels of eriocitrin, a flavonoid that has shown promising effects on GLP-1 and blood sugar regulation.*

Human clinical trials suggest that Eriomin may help support healthy levels of blood glucose by increasing GLP-1 levels, thereby supporting its role in insulin secretion, glucagon suppression, and blood sugar balance.*

In three randomized, double-blind, placebo-controlled clinical trials, Eriomin supplementation (200 mg/day) consistently demonstrated significant improvements in GLP-1 levels. Across these studies, participants experienced an average increase of 17.5% in GLP-1 compared to placebo, with one study showing increases as high as 22%. These findings suggest that Eriomin can effectively support the body's natural GLP-1 production and function.*

Formulation advantages

As a plant-based ingredient, Eriomin offers a well-tolerated, attractive option for health-conscious consumers seeking natural solutions for blood sugar support. Its versatility and neutral taste profile make it easy to incorporate into a wide range of dietary supplement formulations – including capsules, tablets, powders, and functional foods and beverages.

To learn more about Eriomin and explore formulation options, contact us today. Our team of experts is dedicated to helping you develop innovative, science-based products that support consumer health and wellness goals.

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References
  1. Ribeiro, C. B., Ramos, F. M., Manthey, J. A., & Cesar, T. B. (2019). Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study. Phytotherapy Research, 33(7), 1921-1933.
  2. Cesar, T. B., Ramos, F. M. M., & Ribeiro, C. B. (2022). Nutraceutical eriocitrin (Eriomin®) reduces hyperglycemia by increasing glucagon-like peptide 1 and downregulates systemic inflammation: A crossover-randomized clinical trial. Journal of Medicinal Food, 25(11), 1050-1058.
  3. Ramos, F. M., Ribeiro, C. B., Cesar, T. B., Milenkovic, D., Cabral, L., Noronha, M. F., & Sivieri, K. (2023). Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial. Food Science & Nutrition, 00, 1-13.
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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.